Ccdc110-KO Mouse

Ccdc110, also known as KM-HN-1, is a protein-coding gene. It contains a C-terminal coiled-coil domain (CCD), a nuclear localization signal sequence, and a leucine zipper motif. It was previously discovered as a member of the human cancer/testis antigen (CTA). Although its full function remains to be fully identified, it has been implicated in cell cycle progression [1].

In a study, Tet-inducible overexpression of CCDC110 protein in U2-OS osteosarcoma cells delayed the entry of the G2/M phase, suggesting its role in cell cycle regulation [1]. Additionally, in a largely Hispanic population, maternal diabetes was associated with differential methylation of CCDC110 in newborns, indicating a potential link between maternal conditions and fetal epigenetic changes related to Ccdc110 [2]. In a genome-wide analysis of northern Chinese twins, 2 SNPs located in CCDC110 were related to the FEV1/FVC ratio, suggesting its association with pulmonary function [3]. An exome-wide association study in the UK Biobank detected CCDC110 in a burden test for anxiety, indicating a possible role in anxiety-related genetics [4].

In conclusion, Ccdc110 appears to be involved in cell cycle progression, may be affected by maternal diabetes through epigenetic changes, and shows associations with pulmonary function and anxiety. Studies on Ccdc110 contribute to understanding biological processes related to cell cycle, fetal development, pulmonary function, and mental health [1,2,3,4].

References:

1. Lee, Sue Nyoung, Hong, Kyeong-Man, Seong, Yeon Sun, Kwak, Sahng-June. 2020. Ectopic Overexpression of Coiled-Coil Domain Containing 110 Delays G2/M Entry in U2-OS Cells. In Development & reproduction, 24, 101-111. doi:10.12717/DR.2020.24.2.101. https://pubmed.ncbi.nlm.nih.gov/32734127/

2. Rizzo, Heather E, Escaname, Elia N, Alana, Nicholas B, Carr, Nicholas R, Blanco, Cynthia L. 2020. Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population. In Clinical epigenetics, 12, 34. doi:10.1186/s13148-020-0824-9. https://pubmed.ncbi.nlm.nih.gov/32075680/

3. Wang, Tong, Wang, Weijing, Xu, Chunsheng, Tian, Xiaocao, Zhang, Dongfeng. 2024. Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function. In BMC genomics, 25, 1255. doi:10.1186/s12864-024-11165-6. https://pubmed.ncbi.nlm.nih.gov/39736507/

4. Pan, Chuyu, Cheng, Shiqiang, Liu, Li, Jia, Yumeng, Zhang, Feng. 2023. Identification of novel rare variants for anxiety: an exome-wide association study in the UK Biobank. In Progress in neuro-psychopharmacology & biological psychiatry, 130, 110928. doi:10.1016/j.pnpbp.2023.110928. https://pubmed.ncbi.nlm.nih.gov/38154517/