Dzip3-KO Mouse

DZIP3, also known as DAZ-interacting zinc finger 3, is an RNA-binding RING-type ubiquitin ligase. It is involved in multiple biological processes, such as regulating chemokine-or estradiol-induced gene expression, self-renewal, and maintaining pluripotency in mouse embryonic stem cells [4]. It also affects the biological behavior of glioma through the angiogenesis pathway and may be involved in the mechanism of angiogenesis in glioma's invasive biological process [1].

In glioma, DZIP3 expression is related to the World Health Organization (WHO) grade, IDH1 status, and clinical outcome. Lower DZIP3 expression is seen in malignant cases, and it is an independent predictive factor of good prognosis in all grade and lower grade gliomas [1]. In gastric cancer, DZIP3 is significantly up-regulated, promotes proliferation and metastasis of cancer cells, and its higher expression is positively associated with poor prognosis [2]. In cancer cell models, DZIP3 promotes tumor growth and metastasis, and its depletion leads to reduced Cyclin D1 expression, G1 arrest, and defective cell growth [3].

In summary, DZIP3 is a key factor in multiple biological processes and disease conditions. Its role in promoting or inhibiting tumor-related processes in glioma and gastric cancer is significant, as revealed through various functional studies. The findings contribute to understanding the mechanisms of these diseases and may provide potential targets for therapy.

References:

1. Liang, Tingyu, Zhou, Xingang, Li, Peiliang, Wang, Peng, Feng, Enshan. 2020. DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas. In Aging, 12, 24995-25004. doi:10.18632/aging.103817. https://pubmed.ncbi.nlm.nih.gov/33229627/

2. Qiu, Rongfang, Zhao, Siyu, Lu, Chenying, Yang, Yang, Ji, Jiansong. 2023. Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells. In Experimental cell research, 425, 113525. doi:10.1016/j.yexcr.2023.113525. https://pubmed.ncbi.nlm.nih.gov/36841324/

3. Kolapalli, Srinivasa P, Sahu, Rinku, Chauhan, Nishant R, Chauhan, Santosh, Chauhan, Swati. 2020. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. In Cancer research, 81, 315-331. doi:10.1158/0008-5472.CAN-20-1871. https://pubmed.ncbi.nlm.nih.gov/33067265/

4. Oikawa, Daisuke, Shiota, Masayuki, Tokunaga, Fuminori, Wanibuchi, Hideki. 2018. Generation of Rat Monoclonal Antibodies Specific for DZIP3. In Monoclonal antibodies in immunodiagnosis and immunotherapy, 37, 153-157. doi:10.1089/mab.2018.0005. https://pubmed.ncbi.nlm.nih.gov/29812999/