Slc17a9-KO Mouse
Common Name
Slc17a9-KO
제품 ID
S-KO-06223
Backgroud
C57BL/6NCya
품종 계통계통 ID
KOCMP-228993-Slc17a9-B6N-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Slc17a9-KO Mouse (카탈로그 번호 S-KO-06223)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Slc17a9-KO
품종 계통계통 ID
KOCMP-228993-Slc17a9-B6N-VA
유전자명
제품 ID
S-KO-06223
유전자 별칭
Vnut, 1700019H03Rik
배경
C57BL/6NCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 2
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000094218
NCBI 전사체 ID
NM_183161
타겟 영역
Exon 2~12
유효 영역 크기
~8.9 kb
유전자 연구 개요
Slc17a9, also known as VNUT (vesicular nucleotide transporter), functions as an ATP transporter in lysosomes and other secretory vesicles [5]. It is involved in multiple biological processes, such as regulating osteoblast differentiation [8], and may participate in pathways like the PI3K/Akt signaling pathway [7]. Dysregulation of Slc17a9 has been linked to various diseases, highlighting its biological importance.
In cancer research, knockdown of Slc17a9 in renal cancer cells inhibited their proliferation, migration, and invasion, while overexpression led to a more malignant phenotype both in vitro and in vivo, suggesting its role in promoting the progression of clear cell renal cell carcinoma through the SLC17A9-PTHLH-EMT axis [1]. In hepatocellular carcinoma, HHEX-mediated ABI2 upregulated Slc17a9 to promote cancer stem cell-like properties and tumorigenesis [2]. In gastric carcinoma, high Slc17a9 expression was associated with poor overall and recurrence-free survival [3]. In non-small cell lung cancer, Slc17a9 up-regulation was correlated with overall survival, and its knockdown inhibited cell proliferation and ATP levels [4]. In hepatocellular carcinoma, high Slc17a9 expression was related to poor prognosis [6,7]. In colorectal cancer, Slc17a9 overexpression was associated with advanced tumor stages and poor survival, and it was an independent prognostic predictor [9].
In conclusion, Slc17a9 plays a crucial role in regulating cell viability, as well as in the development and progression of multiple cancers. Studies on Slc17a9, especially through loss-of-function experiments in cell lines, have provided valuable insights into its functions in disease processes, potentially offering new targets for cancer diagnosis and treatment.
References:
1. Li, Weiquan, Xu, Ning, Meng, Xiangui, Xiao, Wen, Zhang, Xiaoping. 2022. SLC17A9-PTHLH-EMT axis promotes proliferation and invasion of clear renal cell carcinoma. In iScience, 26, 105764. doi:10.1016/j.isci.2022.105764. https://pubmed.ncbi.nlm.nih.gov/36590170/
2. Li, Huizi, Liu, Jin, Lai, Jie, Zhang, Tong, Gu, Qiuping. 2024. The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC. In Journal of translational medicine, 22, 537. doi:10.1186/s12967-024-05324-2. https://pubmed.ncbi.nlm.nih.gov/38844969/
3. Li, Junqing, Su, Taiqiang, Yang, Liang, Zhang, Changhua, He, Yulong. 2019. High SLC17A9 expression correlates with poor survival in gastric carcinoma. In Future oncology (London, England), 15, 4155-4166. doi:10.2217/fon-2019-0283. https://pubmed.ncbi.nlm.nih.gov/31799885/
4. Gao, Yan, Chen, Yijia, Liu, Min, Ke, Changbin, Pei, Zhijun. 2023. SLC17A9 as a prognostic biomarker correlated with immune infiltrates in human non-small cell lung cancer. In American journal of cancer research, 13, 3963-3982. doi:. https://pubmed.ncbi.nlm.nih.gov/37818081/
5. Huang, Peng, Cao, Qi, Xu, Mengnan, Dong, Xian-Ping. 2022. Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D. In Cells, 11, . doi:10.3390/cells11050887. https://pubmed.ncbi.nlm.nih.gov/35269509/
6. Wu, Jingdong, Yang, Yongfei, Song, Jiansheng. 2020. Expression of SLC17A9 in hepatocellular carcinoma and its clinical significance. In Oncology letters, 20, 182. doi:10.3892/ol.2020.12043. https://pubmed.ncbi.nlm.nih.gov/32934749/
7. Kui, Xue-Yan, Gao, Yan, Liu, Xu-Sheng, Zhang, Yao-Hua, Pei, Zhi-Jun. 2022. Comprehensive Analysis of SLC17A9 and Its Prognostic Value in Hepatocellular Carcinoma. In Frontiers in oncology, 12, 809847. doi:10.3389/fonc.2022.809847. https://pubmed.ncbi.nlm.nih.gov/35957868/
8. Inoue, Asako, Nakao-Kuroishi, Kayoko, Kometani-Gunjigake, Kaori, Kokabu, Shoichiro, Kawamoto, Tatsuo. 2020. VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation. In FEBS open bio, 10, 1612-1623. doi:10.1002/2211-5463.12918. https://pubmed.ncbi.nlm.nih.gov/32592329/
9. Yang, Liang, Chen, Zhihui, Xiong, Weixin, Song, Xinming, Liu, Jia. 2018. High expression of SLC17A9 correlates with poor prognosis in colorectal cancer. In Human pathology, 84, 62-70. doi:10.1016/j.humpath.2018.09.002. https://pubmed.ncbi.nlm.nih.gov/30236596/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
맞춤형 동물 모델 관련 상담을 위해 Cyagen 전문가와 연락해 보세요. 아래 양식을 작성하여 상담을 시작하거나 견적을 요청하시기 바랍니다.
Cyagen은 고객님의 개인정보를 소중히 여깁니다. 최신 제품, 서비스 및 인사이트를 안내드리고자 합니다. 고객님의 수신 설정은 다음과 같습니다:
해당 커뮤니케이션은 언제든지 수신 거부하실 수 있습니다. 수신 거부 방법 및 데이터 보호에 대한 자세한 내용은 개인정보처리방침을 참고해 주시기 바랍니다.
아래 버튼을 클릭함으로써, 요청하신 콘텐츠 제공을 위해 본 양식을 통해 제출된 개인정보를 Cyagen이 저장 및 처리하는 데 동의하게 됩니다.