Ccdc153-KO Mouse

Ccdc153, also known as coiled-coil domain containing 153, is one of the genes identified in a genomic region on chicken chromosome 24. However, the reference does not detail its essential function, associated pathways or overall biological importance. But genetic studies on chicken lines can potentially be valuable research models for understanding gene functions [1].

In a study on dwarf chickens, a genome-wide association analysis was performed to determine the candidate genomic regions underlying white/black tail feather color. The significant region on chromosome 24 (3.97-4.26 Mb) where Ccdc153 is located, was found to be associated with tail feather color. The study revealed that the white/black tail feather trait is autosome-linked, with white being dominant to black. Although the focus was more on the overall region and some genes like MCAM, Ccdc153 is among the genes in this region potentially related to tail feather color determination [1].

In conclusion, while the exact function of Ccdc153 remains to be fully explored, its presence in the genomic region associated with chicken tail feather color indicates its potential role in this specific biological trait. The use of chicken genetic models in this study provides a starting point for further functional studies of Ccdc153, which may help in understanding feather pigmentation mechanisms.

References:

1. Nie, Changsheng, Qu, Liang, Li, Xinghua, Qu, Lujiang, Ning, Zhonghua. 2021. Genomic Regions Related to White/Black Tail Feather Color in Dwarf Chickens Identified Using a Genome-Wide Association Study. In Frontiers in genetics, 12, 566047. doi:10.3389/fgene.2021.566047. https://pubmed.ncbi.nlm.nih.gov/33995468/