Trmt10c-KO Mouse

Trmt10c, also known as tRNA methyltransferase 10C, is a key enzyme involved in RNA modification. It can install N1-methyladenosine (m1A) in RNAs [2]. m1A modification is a post-transcriptional modification that regulates various biological functions, including cell invasion, proliferation, and cell-cycle regulation in cancer [2]. It is also associated with mitochondrial pre-tRNA maturation, compensating for pre-tRNA structural alterations to present it to maturation enzymes [4].

In multiple cancers, Trmt10c has been under intense study. In lung cancer, TRMT10C-mediated m7G modification of circFAM126A inhibits cancer growth by regulating cellular glycolysis [1]. In hepatoblastoma, four polymorphisms in the TRMT10C gene were significantly associated with an increased risk of the disease in Chinese children, indicating its potential role in cancer predisposition [3]. In gynecological cancers, high expression of TRMT10C is related to poorer survival, and silencing it suppresses the proliferation, colony formation, and migration of ovarian and cervical cancer cells [5].

In conclusion, Trmt10c is crucial for RNA modification, especially in the context of m1A and m7G modifications, and is involved in important biological processes. Its role in cancer, including lung cancer, hepatoblastoma, and gynecological cancers, highlights its significance in disease-related research. Studies on Trmt10c provide insights into the molecular mechanisms of cancer development and may offer potential therapeutic targets for these diseases.

References:

1. Zhao, Qingyun, Li, Xiaofei, Wu, Jiaxi, Li, Gang, Nan, Aruo. 2024. TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis. In Cell biology and toxicology, 40, 78. doi:10.1007/s10565-024-09918-w. https://pubmed.ncbi.nlm.nih.gov/39289194/

2. Liu, Yafeng, Zhang, Shujun, Gao, Xiaohui, Gu, Xinyu, Hu, Xinjun. 2024. Research progress of N1-methyladenosine RNA modification in cancer. In Cell communication and signaling : CCS, 22, 79. doi:10.1186/s12964-023-01401-z. https://pubmed.ncbi.nlm.nih.gov/38291517/

3. Liu, Yanfei, Zhu, Jinhong, Wang, Xianqiang, He, Jing, Bian, Jun. 2024. TRMT10C gene polymorphisms confer hepatoblastoma susceptibility: evidence from a seven-center case-control study. In Journal of Cancer, 15, 5396-5402. doi:10.7150/jca.98555. https://pubmed.ncbi.nlm.nih.gov/39247598/

4. Sikarwar, Juhi, Meynier, Vincent, Tisné, Carine. 2025. Advances in Human Pre-tRNA Maturation: TRMT10C and ELAC2 in Focus. In Journal of molecular biology, , 168989. doi:10.1016/j.jmb.2025.168989. https://pubmed.ncbi.nlm.nih.gov/39938738/

5. Wang, Qingying, Zhang, Qinyi, Huang, Yanjuan, Zhang, Jiawen. 2020. m1A Regulator TRMT10C Predicts Poorer Survival and Contributes to Malignant Behavior in Gynecological Cancers. In DNA and cell biology, 39, 1767-1778. doi:10.1089/dna.2020.5624. https://pubmed.ncbi.nlm.nih.gov/32833542/