Fam124a-KO Mouse

Fam124a, Family with sequence similarity 124A, has its function not comprehensively characterized yet from the given references. However, genes can often be studied in relation to associated pathways and diseases through gene knockout (KO) or conditional knockout (CKO) mouse models in functional and in vivo studies.

In a study on cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), antibodies against FAM124A showed higher expression in controls than CADASIL patients, indicating its potential involvement in the disease process [1]. In Jinghai yellow chickens, FAM124A was identified as one of the candidate genes influencing body weight traits through genome-wide association study (GWAS), suggesting its role in growth-related biological processes [2]. In children with severe Mycoplasma pneumoniae pneumonia, FAM124A was among the top 10 most up-regulated genes in bronchoalveolar lavage fluid compared to mild cases, which might be related to the pathogenesis of severe MPP [3].

In conclusion, FAM124A shows potential associations with CADASIL, body weight traits in chickens, and severe Mycoplasma pneumoniae pneumonia. Although direct evidence from KO or CKO mouse models is lacking in these references, these findings imply its importance in disease-related and growth-related biological processes, which could potentially be further explored through such research models.

References:

1. Lee, Soo Jung, Kondepudi, Akhil, Young, Kelly Z, Borjigin, Jimo, Wang, Michael M. 2023. Concentration of non-myocyte proteins in arterial media of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In PloS one, 18, e0281094. doi:10.1371/journal.pone.0281094. https://pubmed.ncbi.nlm.nih.gov/36753487/

2. Zhang, Tao, Wang, Wen-hao, Zhang, Gen-xi, Xue, Qian, Gu, Yu-ping. . [A genome-wide association study on body weight traits of Jinghai yellow chicken]. In Yi chuan = Hereditas, 37, 811-20. doi:10.16288/j.yczz.15-080. https://pubmed.ncbi.nlm.nih.gov/26266784/

3. Wang, Kuo, Gao, Man, Yang, Mingyue, Cheng, Genhong, Wang, Xiaosong. 2017. Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency. In Human genomics, 11, 4. doi:10.1186/s40246-017-0101-y. https://pubmed.ncbi.nlm.nih.gov/28302172/