Pdzk1ip1-KO Mouse

PDZK1IP1, also known as MAP17, encodes a membrane-associated protein. It has been implicated in various cellular processes, and is thought to be involved in cell proliferation-related pathways [2]. Its biological importance lies in its potential roles in multiple diseases, suggesting it could be a significant biomarker or therapeutic target. Genetic models, such as gene knockout (KO) and conditional knockout (CKO) mouse models, can be valuable for further exploring its functions.

In papillary thyroid carcinoma, silencing PDZK1IP1 inhibited cell proliferation, migration, invasion, apoptosis, and caused cell cycle arrest, indicating it may be an oncogene [1]. In goats, overexpression of PDZK1IP1 increased subcutaneous preadipocyte proliferation, while knockdown inhibited it, up-or down-regulating cell proliferation-associated genes respectively [2]. In colorectal carcinoma, a super-enhancer activated PDZK1IP1, which enhanced the reductive capacity of cancer cells via the pentose phosphate pathway, challenging its previous view as a tumor suppressor in CRC [3]. In oral squamous cell carcinoma, knockdown of PDZK1IP1 led to increased migration, metastasis, and epithelial-to-mesenchymal transition (EMT) [4].

In conclusion, PDZK1IP1 is a gene with functions related to cell proliferation, migration, and invasion, as revealed through model-based research. It plays significant roles in multiple cancer-related disease areas, such as papillary thyroid carcinoma, oral squamous cell carcinoma, and colorectal carcinoma. The study of PDZK1IP1 using KO or CKO mouse models could potentially provide more insights into its functions and offer new directions for disease treatment.

References:

1. Zhang, Wei, Zheng, Danni, Jin, Lingli, Zhang, Xiaohua, Chen, Chengze. 2022. PDZK1IP1 gene promotes proliferation, migration, and invasion in papillary thyroid carcinoma. In Pathology, research and practice, 238, 154091. doi:10.1016/j.prp.2022.154091. https://pubmed.ncbi.nlm.nih.gov/36057192/

2. Chen, Dingshuang, Wang, Ruilong, Sheng, Xueqing, Zhu, Jiangjiang, Li, Yanyan. 2022. PDZK1-interacting protein 1(PDZK1IP1) promotes subcutaneous preadipocyte proliferation in goats. In Animal biotechnology, 34, 3063-3073. doi:10.1080/10495398.2022.2132952. https://pubmed.ncbi.nlm.nih.gov/36244042/

3. Zhou, Royce W, Xu, Jia, Martin, Tiphaine C, Bernstein, Emily, Parsons, Ramon E. 2022. A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. In Nature communications, 13, 6041. doi:10.1038/s41467-022-33377-8. https://pubmed.ncbi.nlm.nih.gov/36253360/

4. Hsiao, Sheng-Yen, Weng, Shang-Mei, Hsiao, Jenn-Ren, Chen, Yuh-Ling, Chang, Jang-Yang. 2023. MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition. In Journal of experimental & clinical cancer research : CR, 42, 40. doi:10.1186/s13046-023-02597-1. https://pubmed.ncbi.nlm.nih.gov/36737832/