Isoc2b-KO Mouse

Isoc2b is a gene that appears to be associated with energy production [1]. While its exact function and associated pathways are not comprehensively detailed in the given reference, the gene is mentioned among hypomethylated loci in aged mice. Hypomethylated regions around Isoc2b, along with other loci, were found to be associated with aging processes such as energy production [1].

The study compared age-and tissue-specific methylation differences in the brain and spleen of young and aged mice. Isoc2b was part of the loci with hypomethylation in aged mice, suggesting a possible role in the aging-related energy production processes [1].

In conclusion, Isoc2b seems to be involved in energy production processes, and its hypomethylation in aged mice implies a connection to the aging process. The study of Isoc2b in such age-related models provides insights into the role of methylation changes in genes like Isoc2b during the aging process, potentially contributing to our understanding of age-related metabolic and energy-related diseases [1].

References:

1. Uli, Nishanth, Michelen-Gomez, Eduardo, Ramos, Enrique I, Druley, Todd E. 2018. Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites. In PloS one, 13, e0203147. doi:10.1371/journal.pone.0203147. https://pubmed.ncbi.nlm.nih.gov/30256791/