Ndufs3-KO Mouse
Common Name
Ndufs3-KO
제품 ID
S-KO-12697
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-68349-Ndufs3-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Ndufs3-KO Mouse (카탈로그 번호 S-KO-12697)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Ndufs3-KO
품종 계통계통 ID
KOCMP-68349-Ndufs3-B6J-VA
유전자명
제품 ID
S-KO-12697
유전자 별칭
CI-30kD, 0610010M09Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 2
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000005647
NCBI 전사체 ID
NM_026688
타겟 영역
Exon 3~4
유효 영역 크기
~1.9 kb
유전자 연구 개요
NDUFS3, or NADH dehydrogenase [ubiquinone] ferrithionein 3, is a non-catalytic core subunit of mitochondrial respiratory chain complex I. Complex I is crucial for cellular energy production, and thus NDUFS3 plays an essential role in the energy metabolism of cells. It is associated with various biological processes such as oxidative phosphorylation, which is vital for generating ATP [3,4,5].
In a sepsis-induced acute kidney injury (SI-AKI) rat model, overexpression of NDUFS3 inhibited LPS-induced ferroptosis and mitochondrial damage in HK-2 cells through the AMPK pathway, suggesting its protective role in SI-AKI [1]. In PINK1B9 transgenic Drosophila, down-regulation of NDUFS3 gene expression may have a protective effect, potentially related to reducing oxidative stress and restoring mitochondrial function [7]. In addition, NDUFS3 is underexpressed in atherosclerosis and chronic stress, and lower levels are associated with a worse prognosis [2]. It is also downregulated in atherosclerosis and venous thrombosis, and may serve as a potential biomarker for these diseases [6]. In serous ovarian adenocarcinoma, reduced NDUFS3 expression is correlated with advanced stage, suboptimal residual disease, and shorter survival, suggesting its contribution to the development of this cancer [8].
In conclusion, NDUFS3 is essential for mitochondrial function and energy metabolism. Research using animal models, like the SI-AKI rat model and PINK1B9 transgenic Drosophila, has revealed its roles in various disease conditions including SI-AKI, Parkinson's disease-related models, atherosclerosis, venous thrombosis, and serous ovarian cancer. These findings provide potential therapeutic targets for these diseases by highlighting the importance of NDUFS3-related pathways [1,2,6,7,8].
References:
1. Wang, YuChen, Lv, WuYang, Ma, XiaoTong, Yin, MengJiao, Jin, YingYu. 2024. NDUFS3 alleviates oxidative stress and ferroptosis in sepsis induced acute kidney injury through AMPK pathway. In International immunopharmacology, 143, 113393. doi:10.1016/j.intimp.2024.113393. https://pubmed.ncbi.nlm.nih.gov/39426231/
2. Yang, Yin, Li, Jing-Hui, Yao, Bo-Chen, Wang, Lian-Qun, Guo, Zhi-Gang. 2023. NDUFB11 and NDUFS3 play a role in atherosclerosis and chronic stress. In Aging, 15, 8026-8043. doi:10.18632/aging.204947. https://pubmed.ncbi.nlm.nih.gov/37642954/
3. D'Angelo, Luigi, Astro, Elisa, De Luise, Monica, Fernandez-Vizarra, Erika, Iommarini, Luisa. . NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate. In Cell reports, 35, 109002. doi:10.1016/j.celrep.2021.109002. https://pubmed.ncbi.nlm.nih.gov/33882309/
4. Samanta, Debopam, Veerapandiyan, Aravindhan, Burrow, Thomas A, Gokden, Murat. 2021. Mitochondrial Ultrastructural Defects in NDUFS3-Related Disorder. In Journal of pediatric neurosciences, 16, 299-302. doi:10.4103/jpn.JPN_182_20. https://pubmed.ncbi.nlm.nih.gov/36531773/
5. Yuan, Ningyang, Shen, Lei, Peng, Qian, You, Xue, Feng, Ying. 2024. SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2306871. doi:10.1002/advs.202306871. https://pubmed.ncbi.nlm.nih.gov/38569495/
6. Ma, Yan-Hong, Yang, Yin, Li, Jing-Hui, Guo, Zhi-Gang, Guo, Su-Zhi. . NDUFB11 and NDUFS3 regulate arterial atherosclerosis and venous thrombosis: Potential markers of atherosclerosis and venous thrombosis. In Medicine, 102, e36133. doi:10.1097/MD.0000000000036133. https://pubmed.ncbi.nlm.nih.gov/37986300/
7. Fan, Xueting, Tang, Yafang, Wei, Zaiwa, Cui, Yilei, Li, Qinghua. 2024. Mitochondrial dysfunction and NDUFS3: Insights from a PINK1B9 Drosophila model in Parkinson's disease pathogenesis. In Neuroscience letters, 839, 137917. doi:10.1016/j.neulet.2024.137917. https://pubmed.ncbi.nlm.nih.gov/39102941/
8. Wang, Pei, Cheng, Xiaodong, Fu, Zhiqin, Lu, Weiguo, Xie, Xing. . Reduced expression of NDUFS3 and its clinical significance in serous ovarian cancer. In International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 23, 622-9. doi:10.1097/IGC.0b013e318287a90d. https://pubmed.ncbi.nlm.nih.gov/23446378/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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