Abhd13-KO Mouse

Abhd13, whose functions are still being explored, may be involved in various biological processes. While no common aliases are provided in the given references, its potential roles span across multiple areas. It may be associated with processes such as lipid metabolism considering its differential expression in studies related to meat quality in chickens [5]. Also, its presence in gene lists related to diseases like ALS, Alzheimer's disease, and high myopia implies its possible involvement in relevant pathological pathways [1,3,4]. Genetic models, like gene-targeted mouse models, can be valuable for studying Abhd13's functions.

In a large-scale gene-targeted screen in mice, the Abhd13 knockout mouse strain was among 13 identified with altered nocifensive behavior in nociception and hypersensitivity assays. This finding suggests that Abhd13 may play a role in the genetic mechanisms of inflammatory pain, providing new knowledge for understanding this process and potentially serving as a model for therapeutic target validation and drug development [2].

In conclusion, Abhd13 appears to be involved in multiple biological processes and disease-related pathways. The discovery from the Abhd13 knockout mouse model provides important insights into its role in inflammatory pain. Further research on Abhd13, especially through genetic models, may deepen our understanding of its functions and its implications in various disease conditions such as ALS, Alzheimer's disease, high myopia, and inflammatory pain.

References:

1. Eshak, Deboral, Arumugam, Mohanapriya. 2024. Unveiling therapeutic biomarkers and druggable targets in ALS: An integrative microarray analysis, molecular docking, and structural dynamic studies. In Computational biology and chemistry, 113, 108211. doi:10.1016/j.compbiolchem.2024.108211. https://pubmed.ncbi.nlm.nih.gov/39299050/

2. Wotton, Janine M, Peterson, Emma, Flenniken, Ann M, Mandillo, Silvia, White, Jacqueline K. 2021. Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen. In Pain, 163, 1139-1157. doi:10.1097/j.pain.0000000000002481. https://pubmed.ncbi.nlm.nih.gov/35552317/

3. Horimoto, Andrea R V R, Boyken, Lisa A, Blue, Elizabeth E, Wijsman, Ellen M, Thornton, Timothy A. 2023. Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations. In HGG advances, 4, 100207. doi:10.1016/j.xhgg.2023.100207. https://pubmed.ncbi.nlm.nih.gov/37333771/

4. Swierkowska, Joanna, Karolak, Justyna A, Vishweswaraiah, Sangeetha, Radhakrishna, Uppala, Gajecka, Marzena. . Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children. In Investigative ophthalmology & visual science, 63, 31. doi:10.1167/iovs.63.9.31. https://pubmed.ncbi.nlm.nih.gov/36036911/

5. San, Jishuang, Du, Yanting, Wu, Gaofeng, Yang, Jiancheng, Hu, Jianmin. 2021. Transcriptome analysis identifies signaling pathways related to meat quality in broiler chickens - the extracellular matrix (ECM) receptor interaction signaling pathway. In Poultry science, 100, 101135. doi:10.1016/j.psj.2021.101135. https://pubmed.ncbi.nlm.nih.gov/33940279/