Name: Gsdmd-KO Mouse
Brand: 싸이아젠(Cyagen)
SKU: S-KO-12963

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Gsdmd-KO Mouse

Common Name

Gsdmd-KO

제품 ID

S-KO-12963

Backgroud

C57BL/6NCya

품종 계통계통 ID

KOCMP-69146-Gsdmd-B6N-VA

상태

이 마우스 계통을 논문에서 사용할 경우, “Gsdmd-KO Mouse (카탈로그 번호 S-KO-12963)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.

KO Models

구매 가능한 제품 종류

연령

Genotype

성별

수량

표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.

가격 문의

KO Models

기본 정보

품종 계통

Gsdmd-KO

품종 계통계통 ID

KOCMP-69146-Gsdmd-B6N-VA

유전자명

Gsdmd

제품 ID

S-KO-12963

유전자 별칭

배경

C57BL/6NCya

유전자 공식 전체 명칭

gasdermin D

NCBI ID

69146

변형 내용

Conventional knockout

염색체

Chr 15

Phenotype

MGI:1916396

Datasheet

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적용 분야

품종 계통 설명

Ensembl 전사체 ID

ENSMUST00000023238

NCBI 전사체 ID

NM_026960

타겟 영역

Exon 2~11

유효 영역 크기

~4.3 kb

유전자 연구 개요

Gasdermin D (Gsdmd) is a key executor in pyroptosis, a form of programmed cell death. Inflammatory caspases, such as caspase-1,-4,-5 and-11, cleave Gsdmd, which is essential for pyroptosis induction. This process is involved in innate defenses, and Gsdmd-related pyroptosis has significance in host defense, inflammatory and autoimmune diseases [1,3].

Genetic KO of Gsdmd in mice alleviated depression-like behaviors and inhibited pyroptosis-associated protein expression, indicating its role in astrocyte pathological injury in depression [2]. In obstructive nephropathy, Gsdmd deletion in neutrophils protected the kidney from fibrosis as Gsdmd-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis [4].

In conclusion, Gsdmd is crucial in pyroptosis, playing significant roles in diseases like depression and renal fibrosis. The use of Gsdmd KO mouse models has been instrumental in revealing its functions in these specific disease conditions, providing insights into disease mechanisms and potential therapeutic targets.

References:

1. Shi, Jianjin, Zhao, Yue, Wang, Kun, Wang, Fengchao, Shao, Feng. 2015. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. In Nature, 526, 660-5. doi:10.1038/nature15514. https://pubmed.ncbi.nlm.nih.gov/26375003/

2. Li, Shanshan, Sun, Yiming, Song, Mengmeng, Lu, Ming, Hu, Gang. 2021. NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression. In JCI insight, 6, . doi:10.1172/jci.insight.146852. https://pubmed.ncbi.nlm.nih.gov/34877938/

3. Li, Zihao, Ji, Senlin, Jiang, Mei-Ling, Xu, Yun, Zhang, Cun-Jin. 2022. The Regulation and Modification of GSDMD Signaling in Diseases. In Frontiers in immunology, 13, 893912. doi:10.3389/fimmu.2022.893912. https://pubmed.ncbi.nlm.nih.gov/35774778/

4. Wang, Yujia, Li, Yinshuang, Chen, Zhimin, Chen, Hong, Xu, Yanfang. 2022. GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy. In Cell death & disease, 13, 693. doi:10.1038/s41419-022-05138-4. https://pubmed.ncbi.nlm.nih.gov/35941120/