Mtfr2-KO Mouse
Common Name
Mtfr2-KO
제품 ID
S-KO-13685
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-71804-Mtfr2-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Mtfr2-KO Mouse (카탈로그 번호 S-KO-13685)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Mtfr2-KO
품종 계통계통 ID
KOCMP-71804-Mtfr2-B6J-VA
유전자명
제품 ID
S-KO-13685
유전자 별칭
Dufd1, Fam54a, 2610016C23Rik, 4933412C16Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 10
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000169712
NCBI 전사체 ID
NM_027930
타겟 영역
Exon 3~5
유효 영역 크기
~2.1 kb
유전자 연구 개요
MTFR2, short for Mitochondrial fission regulator 2, belongs to the MTFR1 family and is crucial for regulating mitochondrial fission. It is also involved in metabolic reprogramming, particularly the shift from oxidative phosphorylation to glycolysis. MTFR2-related pathways include the Akt signaling pathway, and it is associated with important biological processes such as cancer-immunity cycle [2,3,4,7].
In hepatocellular carcinoma (HCC), MTFR2-dependent mitochondrial fission promotes HCC progression. Patients with heightened mitochondrial fission due to up-regulated MTFR2 have a worse prognosis. Down-regulation of MTFR2 in HCC cells blocks malignant behaviors, epithelial-to-mesenchymal transition (EMT), and glycolysis [1,3]. In oral squamous carcinoma, MTFR2 promotes cell proliferation, migration, and invasion by switching OXPHOS to glycolysis [4]. In lung adenocarcinoma, knockdown of MTFR2 inhibits cell proliferation, migration, and invasion via AKT-cyclin D1 signaling and EMT pathways [5]. In gastric cancer, down-regulation of MTFR2 inhibits the proliferation, migration, and invasion of GC cells in vitro and in vivo [6]. In breast cancer, knockdown of MTFR2 reduces the capacity for migration and invasion, and MTFR2 can switch glucose metabolism from OXPHS to glycolysis in a HIF1α-and HIF2α-dependent manner [7]. In endometrial carcinoma, MTFR2 promotes cell proliferation and growth through the miR-132-3p/PI3K/Akt signaling pathway [8].
In conclusion, MTFR2 plays a significant role in promoting the progression of multiple cancers, mainly through regulating mitochondrial fission and metabolic reprogramming. Loss-of-function experiments in various cancer cell lines have revealed its importance in processes like cell proliferation, migration, invasion, and metabolic shifts. Understanding MTFR2 provides potential targets for cancer therapy.
References:
1. Zhang, La, Zhang, Xiuzhen, Liu, Haichuan, Zhou, Baoyong, Jiang, Ning. 2024. MTFR2-dependent mitochondrial fission promotes HCC progression. In Journal of translational medicine, 22, 73. doi:10.1186/s12967-023-04845-6. https://pubmed.ncbi.nlm.nih.gov/38238834/
2. Huang, Qiaoqiao, Han, Ying, Shen, Edward, Cai, Changjing, Shen, Hong. 2022. MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma. In iScience, 26, 105095. doi:10.1016/j.isci.2022.105095. https://pubmed.ncbi.nlm.nih.gov/36713263/
3. Bao, Zhongming, Yang, Ming, Guo, Yunhu, Ge, Qi, Zhang, Huaguo. 2024. MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway. In Cellular signalling, 123, 111366. doi:10.1016/j.cellsig.2024.111366. https://pubmed.ncbi.nlm.nih.gov/39182591/
4. Wang, Wei, Xiong, Meihua, Jiang, Lin, Chen, Zean, Shao, Yisen. 2020. MTFR2 Promotes the Proliferation, Migration, and Invasion of Oral Squamous Carcinoma by Switching OXPHOS to Glycolysis. In Frontiers in oncology, 10, 858. doi:10.3389/fonc.2020.00858. https://pubmed.ncbi.nlm.nih.gov/32537437/
5. Lian, Zengzhi, Pang, Pei, Zhu, Yan, Du, Wenwen, Zhou, Jintao. 2022. Prognostic Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma. In Frontiers in oncology, 12, 832517. doi:10.3389/fonc.2022.832517. https://pubmed.ncbi.nlm.nih.gov/35600359/
6. Zhu, Hai, Wang, Gang, Zhu, Haixing, Xu, Aman. 2021. MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments. In Journal of Cancer, 12, 3611-3625. doi:10.7150/jca.58158. https://pubmed.ncbi.nlm.nih.gov/33995638/
7. Lu, Guanming, Lai, Yuanhui, Wang, Tiantian, Liu, Ruilei, Li, Jie. 2019. Mitochondrial fission regulator 2 (MTFR2) promotes growth, migration, invasion and tumour progression in breast cancer cells. In Aging, 11, 10203-10219. doi:10.18632/aging.102442. https://pubmed.ncbi.nlm.nih.gov/31740625/
8. Niu, Zhijun, Zhang, Yue, Wang, Yishan, Xu, Xia, Li, Lei. 2025. MTFR2 promotes endometrial carcinoma cell proliferation and growth via the miR-132-3p/PI3K/Akt signaling pathway. In Frontiers in medicine, 11, 1505071. doi:10.3389/fmed.2024.1505071. https://pubmed.ncbi.nlm.nih.gov/40129972/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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