Spatc1-KO Mouse

Spatc1, or Spermatogenesis and Centriole Associated 1, is a gene with a significant role in spermatogenesis. It is associated with pathways related to sperm function and male reproduction. Genetic models, such as mouse models, can be valuable for studying its functions [1,2].

In mice, chronic administration of ghrelin, which impairs spermatogenesis, leads to a relative decrease in Spatc1 expression, suggesting its involvement in the process regulated by ghrelin [3]. Also, male mice with a truncation mutation in Basonuclin 1 (BNC1) exhibit fertility loss and testicular premature aging, and Spatc1 was identified as one of the spermatogenesis-specific gene promoters targeted by BNC1, indicating a cooperative role in regulating spermatogenesis [4].

In conclusion, Spatc1 is crucial for spermatogenesis and male reproduction. Mouse models, especially those with mutations affecting Spatc1 expression, have provided insights into its role in processes related to male fertility, helping to understand the mechanisms underlying infertility and testicular aging [3,4].

References:

1. Liu, Xu, Liu, Xuyuan, Wang, Xinqi, He, Miao, Fan, Zhenxin. 2023. Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques. In BMC genomics, 24, 308. doi:10.1186/s12864-023-09404-3. https://pubmed.ncbi.nlm.nih.gov/37286946/

2. An, Yeeun, Lee, Chaeyoung. 2022. Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance. In Computational biology and chemistry, 99, 107713. doi:10.1016/j.compbiolchem.2022.107713. https://pubmed.ncbi.nlm.nih.gov/35709667/

3. Belén Poretti, María, Bianconi, Santiago, Luque, Eugenia, Schiöth, Helgi B, Carlini, Valeria Paola. 2022. Role of the hypothalamus in ghrelin effects on reproduction: sperm function and sexual behavior in male mice. In Reproduction (Cambridge, England), 165, 123-134. doi:10.1530/REP-22-0098. https://pubmed.ncbi.nlm.nih.gov/36322468/

4. Li, Jing-Yi, Liu, Yi-Feng, Xu, Hai-Yan, Zhang, Dan, Huang, He-Feng. . Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. In Journal of molecular cell biology, 12, 71-83. doi:10.1093/jmcb/mjz035. https://pubmed.ncbi.nlm.nih.gov/31065688/