Ppp1r1c-KO Mouse

Ppp1r1c, also known as thymocyte cyclic AMP-regulated phosphoprotein (TARPP), is involved in multiple biological processes. It has been associated with neural outgrowth [2], and may play a role in cell cycle regulation [3]. In the context of neural circuits, it is among the genes upregulated during the regeneration of afferent neurons to cochlear hair cells [2]. In human Wharton's Jelly mesenchymal stem cells, its expression pattern is closely related to negative cell cycle regulation and cell cycle arrest processes [3].

In glioblastoma, miR-182 targets Ppp1r1c. The inverse correlation between Ppp1r1c protein/RNA expression and miR-182 expression was observed in glioblastoma patients and U87-MG cells. Ectopic expression of miR-182 mimic decreased proliferation, migration, and invasion in U87-MG cells, and both miR-182 mimic and siRNA targeting Ppp1r1c induced temozolomide susceptibility, indicating that high Ppp1r1c expression may contribute to decreased susceptibility to TMZ in GBM patients [1].

In summary, Ppp1r1c is involved in neural outgrowth and cell cycle-related processes. In glioblastoma, its regulation by miR-182 has implications for disease progression and drug susceptibility, highlighting the importance of understanding Ppp1r1c functions in disease-related research [1,2,3].

References:

1. Liu, Liqiang, Zhang, Xiaowei, Nan, Chengrui, Hu, Hongchao, Liang, Zhaohui. 2017. MicroRNA-182 targets protein phosphatase 1 regulatory inhibitor subunit 1C in glioblastoma. In Oncotarget, 8, 114677-114684. doi:10.18632/oncotarget.21309. https://pubmed.ncbi.nlm.nih.gov/29383111/

2. Wu, Chen-Chi, Brugeaud, Aurore, Seist, Richard, Edge, Albert S B, Stankovic, Konstantina M. 2020. Altered expression of genes regulating inflammation and synaptogenesis during regrowth of afferent neurons to cochlear hair cells. In PloS one, 15, e0238578. doi:10.1371/journal.pone.0238578. https://pubmed.ncbi.nlm.nih.gov/33001981/

3. Ramarao, Kivaandra Dayaa Rao, Somasundram, Chandran, Razali, Zuliana, Musa, Sabri, Achari, Vijayan Manickam. 2022. Antiproliferative effects of dried Moringa oleifera leaf extract on human Wharton's Jelly mesenchymal stem cells. In PloS one, 17, e0274814. doi:10.1371/journal.pone.0274814. https://pubmed.ncbi.nlm.nih.gov/36197921/