Ttc23l-KO Mouse

Ttc23l, a gene of significance, is likely involved in various biological processes. However, specific details about its aliases, essential functions, associated pathways are not elaborated in the provided references. But genes with which it was co-detected in a study were related to immune system, stress response, reproduction, embryo development, and carbohydrate and lipid metabolism, hinting at its potential role in similar processes [1].

In a study on rabbits selected for environmental variance of litter size, Ttc23l was among the genes with functional mutations. A functional mutation in Ttc23l was fixed in one rabbit line and absent in the other, suggesting its possible role in controlling the environmental variance of litter size and potentially animal resilience. However, functional analyses are needed to fully assess its implications [1].

In conclusion, Ttc23l may play a role in processes related to the environment-related variance of litter size and animal resilience in rabbits, as indicated by the presence of a fixed functional mutation in one of the divergent rabbit lines. Further functional studies are required to fully understand its biological functions and its potential contribution to these and other related areas.

References:

1. Casto-Rebollo, Cristina, Argente, María José, García, María Luz, Blasco, Agustín, Ibáñez-Escriche, Noelia. 2021. Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience. In Genetics, selection, evolution : GSE, 53, 59. doi:10.1186/s12711-021-00653-y. https://pubmed.ncbi.nlm.nih.gov/34256696/