Dlgap5-KO Mouse
Common Name
Dlgap5-KO
제품 ID
S-KO-15726
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-218977-Dlgap5-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Dlgap5-KO Mouse (카탈로그 번호 S-KO-15726)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Dlgap5-KO
품종 계통계통 ID
KOCMP-218977-Dlgap5-B6J-VA
유전자명
제품 ID
S-KO-15726
유전자 별칭
Dlg7, Hurp, Dap-5, mKIAA0008
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 14
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000043296
NCBI 전사체 ID
NM_144553
타겟 영역
Exon 3~15
유효 영역 크기
~20.8 kb
유전자 연구 개요
Dlgap5, also known as DLG7, encodes a microtubule-associated protein DLG7 which is crucial during spindle assembly. Spindle assembly regulation is vital for maintaining genomic stability, thus Dlgap5 is of great biological importance in cell division processes [8].
In multiple cancer types, Dlgap5 shows oncogenic properties. In lung adenocarcinoma, its high expression is associated with poor prognosis, and it promotes cancer growth by upregulating PLK1 [1]. In bladder cancer, it triggers cell proliferation and metastasis by stabilizing E2F1 via USP11, and also enhances chemoresistance by regulating glycolysis through MYC stabilization [2,3]. In prostate adenocarcinoma, it promotes neuroendocrine differentiation by upregulating E2F1 [4]. In endometrial cancer, knockdown of Dlgap5 inactivates the Wnt/β-catenin signal to repress cell malignant activities [5]. In gallbladder cancer, it promotes migration and tumor-associated macrophage M2 polarization by activating cAMP [6]. In breast cancer, it regulates cell proliferation, migration, invasion, and cell cycle via the JAK2/STAT3 signaling axis [7]. In colorectal cancer, its downregulation reduces invasion and migration potential, and overexpression is linked to poor survival in non-metastatic patients [8]. In ovarian cancer, knockdown of Dlgap5 suppresses cell proliferation, induces G2/M phase arrest and apoptosis [9].
In conclusion, Dlgap5 plays a significant role in cell division-related processes and is closely associated with the development and progression of various cancers. Functional studies, especially those using knockdown models in different cancer cell lines, have revealed its oncogenic functions in promoting cancer cell proliferation, migration, invasion, and in some cases, regulating cancer-related signaling pathways. This understanding of Dlgap5's role in cancer provides potential therapeutic targets for treating these malignancies.
References:
1. Chen, Maojian, Zhang, Shaoping, Wang, Fan, Jiang, Wei, Zhang, Li. 2024. DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target. In Journal of translational medicine, 22, 209. doi:10.1186/s12967-024-04910-8. https://pubmed.ncbi.nlm.nih.gov/38414025/
2. Zhou, Fenfang, Deng, Zhao, Shen, Dexin, Ju, Lingao, Wang, Xinghuan. 2024. DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11. In Oncogene, 43, 594-607. doi:10.1038/s41388-023-02932-y. https://pubmed.ncbi.nlm.nih.gov/38182895/
3. Deng, Zhao, Zhou, Fenfang, Li, Mingxing, Xiao, Yu, Wang, Xinghuan. 2025. DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization. In Theranostics, 15, 2375-2392. doi:10.7150/thno.102730. https://pubmed.ncbi.nlm.nih.gov/39990228/
4. Liang, Linghui, Shen, Zhiyi, Zhang, Kaiyu, Zhao, Ruizhe, Feng, Ninghan. 2025. DLGAP5 upregulates E2F1 to promote prostate adenocarcinoma neuroendocrine differentiation. In Life sciences, 365, 123442. doi:10.1016/j.lfs.2025.123442. https://pubmed.ncbi.nlm.nih.gov/39923838/
5. Chen, Ruipu, Liu, Jing, Hu, Jun, Liu, Yanhua, Pan, Weiwei. 2022. DLGAP5 knockdown inactivates the Wnt/β-catenin signal to repress endometrial cancer cell malignant activities. In Environmental toxicology, 38, 685-693. doi:10.1002/tox.23720. https://pubmed.ncbi.nlm.nih.gov/36454672/
6. Huang, Jie, Zheng, Mengyao, Li, Yan, Xu, Dingwei, Tian, Daguang. 2023. DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP. In Cancer immunology, immunotherapy : CII, 72, 3203-3216. doi:10.1007/s00262-023-03484-6. https://pubmed.ncbi.nlm.nih.gov/37421434/
7. Li, Yujie, Wei, Jie, Sun, Yao, Zhang, Huan, Jin, Tianbo. 2023. DLGAP5 Regulates the Proliferation, Migration, Invasion, and Cell Cycle of Breast Cancer Cells via the JAK2/STAT3 Signaling Axis. In International journal of molecular sciences, 24, . doi:10.3390/ijms242115819. https://pubmed.ncbi.nlm.nih.gov/37958803/
8. Branchi, Vittorio, García, Sebastián A, Radhakrishnan, Praveen, Reißfelder, Christoph, Schölch, Sebastian. 2019. Prognostic value of DLGAP5 in colorectal cancer. In International journal of colorectal disease, 34, 1455-1465. doi:10.1007/s00384-019-03339-6. https://pubmed.ncbi.nlm.nih.gov/31286215/
9. Zhang, Huijun, Liu, Yuan, Tang, Shengchun, Zhang, Jing, Liu, Bo. 2021. Knockdown of DLGAP5 suppresses cell proliferation, induces G2/M phase arrest and apoptosis in ovarian cancer. In Experimental and therapeutic medicine, 22, 1245. doi:10.3892/etm.2021.10680. https://pubmed.ncbi.nlm.nih.gov/34539841/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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