Osbpl11-KO Mouse

Osbpl11, short for oxysterol-binding protein-like protein 11, belongs to the OSBP family of intracellular receptors. It is involved in lipid binding and transport, and is likely to play a role in cholesterol and glucose metabolism [2]. Genetic models could potentially help in further exploring its functions and associated pathways.

In acute myeloid leukemia (AML), overexpression of OSBPL11 reversed the tumor-suppressive effects of miR-7-5p, which curbed cellular proliferation and promoted apoptosis in AML cells. Exo-miR-7-5p from bone marrow mesenchymal stem cells inhibited OSBPL11 expression through the PI3K/AKT/mTOR signaling pathway, thus inhibiting AML development [1]. In obesity, certain polymorphisms in the OSBPL11 gene were associated with cardiovascular disease risk factors such as diastolic blood pressure, low-density lipoprotein-cholesterol levels, hyperglycemia/diabetes, and metabolic syndrome [2]. In hepatocellular carcinoma, downregulated OSBPL11 may be a potential indicator [3]. In pancreatic ductal adenocarcinoma, the expression of OSBPL11 was highly upregulated, and the functions of OSBPL family members (including OSBPL11) were associated with several potential signaling pathways in cancer cells [4].

In conclusion, Osbpl11 is involved in lipid-related processes and has implications in multiple disease areas. Its role in AML, obesity-related cardiovascular risks, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma, as revealed through various studies, highlights its importance in understanding disease mechanisms. Research on Osbpl11 can potentially provide new insights for disease treatment and prevention strategies in these areas.

References:

1. Jiang, Duanfeng, Wu, Xin, Sun, Xiaoying, Du, Ashuai, Zhao, Qiangqiang. 2022. Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11. In Journal of nanobiotechnology, 20, 29. doi:10.1186/s12951-021-01206-7. https://pubmed.ncbi.nlm.nih.gov/35012554/

2. Bouchard, Luigi, Faucher, Geneviève, Tchernof, André, Pérusse, Louis, Vohl, Marie-Claude. 2009. Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity. In Obesity (Silver Spring, Md.), 17, 1466-72. doi:10.1038/oby.2009.71. https://pubmed.ncbi.nlm.nih.gov/19325544/

3. Peng, Huifang, Yan, Zhijian, Zeng, Xinhua, Huang, Heqing, Zhuo, Huiqin. 2019. Serum and tissue proteomic signatures of patients with hepatocellular carcinoma using 2‑D gel electrophoresis. In Molecular medicine reports, 20, 1025-1038. doi:10.3892/mmr.2019.10311. https://pubmed.ncbi.nlm.nih.gov/31173207/

4. Chou, Cheng-Wei, Hsieh, Yu-Hsiu, Ku, Su-Chi, Wang, Chih-Yang, Wang, Wei-Jan. 2021. Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma. In Biomedicines, 9, . doi:10.3390/biomedicines9111601. https://pubmed.ncbi.nlm.nih.gov/34829830/