Ddo-KO Mouse

Ddo, whose full name is D-aspartate oxidase, is an enzyme-encoding gene involved in the peroxisome-related pathways [1]. Peroxisomes are associated with lipid metabolism and regulation of reactive oxygen species, highlighting the potential importance of Ddo in maintaining cellular homeostasis.

In a study on non-small cell lung cancer (NSCLC), genetic variants in Ddo were investigated. The SNP rs9384742 in Ddo was significantly associated with NSCLC overall survival. The minor allele of rs9384742 was associated with decreased Ddo messenger RNA (mRNA) expression levels, and Ddo expression was also decreased in NSCLC tumor tissue. This indicates that Ddo may play a role in the development and progression of NSCLC [1].

In conclusion, Ddo's involvement in peroxisome-related pathways suggests its importance in cellular processes related to lipid metabolism and oxidative stress regulation. The discovery of its genetic variants associated with NSCLC survival provides insights into the role of Ddo in this cancer, highlighting the potential of Ddo as a biomarker or therapeutic target in NSCLC research [1].

References:

1. Chen, Allan S, Liu, Hongliang, Wu, Yufeng, Christiani, David C, Wei, Qingyi. 2022. Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival. In Molecular carcinogenesis, 61, 619-628. doi:10.1002/mc.23400. https://pubmed.ncbi.nlm.nih.gov/35502931/