Septin6-KO Mouse

Septin6 is a GTP-binding protein belonging to the septin family. Septins are implicated in cytoskeleton and membrane organization, cell division, and host-pathogen interactions [4]. Septin6 has been shown to be involved in pathways such as the mTORC1 pathway, which is crucial for cell growth and protein synthesis [2].

In leukemia research, Septin6 has been found to be involved in rare MLL (now KMT2A) rearrangements. For instance, in acute monocytic leukemia and acute myeloid leukemia, the 5'-MLL/SEPTIN6-3' chimeric transcript has been identified, often resulting from complex or cryptic chromosomal rearrangements [1,3,5,6]. In dairy cow mammary epithelial cells, over-expressing or inhibiting Septin6 affects cell growth and casein synthesis via the mTORC1 pathway, indicating its role in cell growth regulation [2]. Also, Septin6 and Septin7 complexes are involved in regulating protein sorting during multivesicular body biogenesis, influencing the membrane interactions of AP-3 and ESCRT-I [4].

In conclusion, Septin6 plays essential roles in cell growth regulation, protein sorting during multivesicular body biogenesis, and is implicated in the pathogenesis of certain leukemia types. Studies on Septin6 contribute to understanding these biological processes and the underlying mechanisms of related diseases, with potential implications for diagnosis and treatment in leukemia [1,2,3,4,5,6].