Scaf11-KO Mouse

SCAF11, also known as SR-related CTD associated factor 11, has been implicated in multiple biological functions and pathways. It has been associated with the ubiquitin-mediated proteolysis pathway [3], and may be involved in processes related to inflammation, immune-related signaling pathways such as oxidative phosphorylation, antimicrobial humoral response, and immunoglobulin complex according to functional enrichment analysis [1].

In breast cancer, knocking down SCAF11 inhibits cell viability and colony-formation, and its expression is significantly correlated with diverse tumor-infiltrating lymphocytes and immune checkpoints, suggesting its role in regulating the immune microenvironment [1].

In hepatocellular carcinoma, suppression of SCAF11 expression inhibits the proliferation, migration, invasion, and induces apoptosis of liver cancer cell lines, indicating that SCAF11 promotes the progression of liver cancer [2].

In conclusion, SCAF11 is involved in multiple biological processes and pathways. Studies using loss-of-function experiments in cancer cell lines have revealed its role in promoting cancer progression in breast and liver cancers, highlighting its potential as a therapeutic target in these disease areas.