Fosb-KO Mouse

Fosb, short for FBJ Murine Osteosarcoma Viral Oncogene Homolog B, is a proto-oncogene. It belongs to the Fos family of transcription factors. As a transcription factor, Fosb can regulate the expression of specific target genes, thus participating in a wide variety of biological processes. It is involved in tumorigenic processes and may regulate neuronal excitability and synaptic plasticity in the nervous system [1,2,3].

In glioma, knockdown of FosB led to decreased cell viability, proliferation, and migration, suggesting FosB may promote glioma development and migration [4]. In APP mice, persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection to hippocampal dentate granule cells [2]. In mast cells of male mice, FosB/ΔFosB activation modulates allergic inflammation by regulating gene expression, likely through enhanced DUSP4 expression [5].

In conclusion, FosB plays significant roles in tumorigenesis, seizure regulation, and allergic inflammation. Gene-knockout or conditional-knockout mouse models have been crucial in revealing these functions, contributing to our understanding of related diseases such as glioma, epilepsy-related conditions in Alzheimer's disease models, and allergic inflammation.