Boll-KO Mouse

BOLL, also known as boule, has been associated with several biological processes and disease conditions. In genetic studies, its loci have shown significance in certain pathways. For instance, in relation to intracranial aneurysm (IA), genome-wide association studies have reported an association between BOLL and endothelin receptor type A (EDNRA) loci. Pair-wise interaction analyses in a Korean adult cohort indicated that rather than a single-SNP effect of BOLL or EDNRA on IA development, they showed a synergistic effect on IA formation via multifactorial pair-wise interactions [1].

In gastric cancer research, BOLL has been identified as a critical RNA-binding protein (RBP). A prognostic risk model, established by screening differentially expressed RBP genes from the TCGA database, led to the discovery that BOLL is associated with mitochondrial function. Gene Set Enrichment analysis (GSEA) supported this finding. In vitro and in vivo experiments demonstrated that circ_0088300 upregulates the expression level of BOLL, and this upregulation promotes gastric cancer growth and metastasis by promoting mitochondrial metabolic reprogramming [2].

In conclusion, BOLL plays important roles in both intracranial aneurysm formation through its interaction with EDNRA and in gastric cancer growth and metastasis by regulating mitochondrial metabolic reprogramming. These findings from functional studies provide insights into the biological functions of BOLL and its implications in disease-related processes, which could potentially contribute to the development of new strategies for disease treatment and prevention.