Tars3-KO Mouse

Tars3 is not mentioned in the provided references. However, TARSL2, a related gene, encodes a threonyl-tRNA synthetase-like protein (ThrRS-L) in higher eukaryotes. TARS and TARS2 encode cytoplasmic and mitochondrial threonyl-tRNA synthetases respectively, while TARSL2-encoded ThrRS-L has sequence homology to cytoplasmic ThrRS but a distinct N-terminal extension. ThrRS-L is involved in tRNA aminoacylation and editing, which are crucial processes in protein synthesis [1].

In glioma research, miR-720 was found to be upregulated in glioma tissues and cells. miR-720 promotes glioma migration and invasion by downregulating TARSL2. Reintroduction of TARSL2 into glioma cells can repress the invasion-promoting function of miR-720 [2]. Additionally, TARSL2 was identified as a potential member of the aminoacyl-tRNA synthetase core complex through affinity purification-mass spectrometry and co-immunoprecipitation experiments [3].

In conclusion, TARSL2 plays important roles in protein synthesis-related processes such as tRNA aminoacylation and editing. In glioma, its regulation by miR-720 is significant for understanding glioma migration and invasion. Identifying it as a potential component of the aminoacyl-tRNA synthetase core complex also provides new insights into the complex's function. The study of TARSL2 helps in understanding biological processes and disease mechanisms, potentially offering new strategies for glioma treatment.