Serpind1-KO Mouse
Common Name
Serpind1-KO
제품 ID
S-KO-18880
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-15160-Serpind1-B6J-VB
상태
이 마우스 계통을 논문에서 사용할 경우, “Serpind1-KO Mouse (카탈로그 번호 S-KO-18880)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Serpind1-KO
품종 계통계통 ID
KOCMP-15160-Serpind1-B6J-VB
유전자명
제품 ID
S-KO-18880
유전자 별칭
HCII, Hcf2, HC-II
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 16
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000023450
NCBI 전사체 ID
NM_008223
타겟 영역
Exon 3
유효 영역 크기
~0.3 kb
유전자 연구 개요
Serpind1, also known as heparin cofactor II, belongs to the serine protease inhibitor family. Some serpins, including Serpind1, utilize glycosaminoglycans (GAGs) to enhance the inhibition of target proteases [2].
In epithelial ovarian cancer, Serpind1 expression is significantly elevated, and high expression is associated with poor prognosis. Serpind1 promotes the proliferation, migration, invasion, G1-to-S phase transition, and epithelial-mesenchymal transition of ovarian cancer cells, while inhibiting apoptosis by promoting phosphorylation in the PI3K/AKT pathway. Inhibition of Serpind1 expression in ovarian cancer cells has opposite effects, and adding the PI3K/AKT pathway inhibitor to Serpind1-overexpressing cells can reverse its promoting effect on the malignant biological behavior of ovarian cancer cells [1].
In glaucoma, Serpind1 shows significant upregulation and plays a vital role in glaucoma occurrences, being associated with eye transparency decrease and glucose metabolism [3].
In patients with systemic sclerosis-associated pulmonary hypertension, the expression of Serpind1 is increased in the survivor group compared to the non-survivor group [4].
In intrahepatic cholestasis of pregnancy, the expression level of Serpind1 is remarkably lower in ICP patients than in healthy pregnant females, and it has a negative correlation with total bile acid (TBA) [5]. Polycyclic aromatic hydrocarbons (PAHs) accelerate the development of arteriosclerosis by promoting the expression of miR-155 to downregulate Serpind1 [6].
In conclusion, Serpind1 is a serine protease inhibitor that can interact with GAGs. Through studies in various disease models, it has been shown to play important roles in cancer (such as epithelial ovarian cancer), glaucoma, systemic sclerosis-associated pulmonary hypertension, intrahepatic cholestasis of pregnancy, and atherosclerosis. These findings from different disease-related research help to understand its biological functions and the potential for it to be a biomarker or therapeutic target in these diseases.
References：
1. Guo, Qian, Zhu, Liancheng, Wang, Caixia, Li, Xiao, Lin, Bei. 2019. SERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study. In Frontiers in oncology, 9, 954. doi:10.3389/fonc.2019.00954. https://pubmed.ncbi.nlm.nih.gov/31637210/
2. Rein, Chantelle M, Desai, Umesh R, Church, Frank C. . Serpin-glycosaminoglycan interactions. In Methods in enzymology, 501, 105-37. doi:10.1016/B978-0-12-385950-1.00007-9. https://pubmed.ncbi.nlm.nih.gov/22078533/
3. Liu, Xiaoyan, Liu, Xiang, Wang, Ying, Xu, Jiyu, Sun, Wei. 2021. Proteome Characterization of Glaucoma Aqueous Humor. In Molecular & cellular proteomics : MCP, 20, 100117. doi:10.1016/j.mcpro.2021.100117. https://pubmed.ncbi.nlm.nih.gov/34214668/
4. Mismetti, Valentine, Delavenne, Xavier, Montani, David, Bertoletti, Laurent, Cottin, Vincent. 2023. Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension. In Respiratory research, 24, 273. doi:10.1186/s12931-023-02578-0. https://pubmed.ncbi.nlm.nih.gov/37936223/
5. Chen, Lingyan, Li, Jingyang, You, Yilan, Xiao, Jianping, Zhang, Yan. 2023. Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study. In Heliyon, 9, e21616. doi:10.1016/j.heliyon.2023.e21616. https://pubmed.ncbi.nlm.nih.gov/38027820/
6. He, Xiao-Nan, Xin, Jin-Yuan, Zhan, Jin-Liang, Zhang, Xiao-Ling, Bai, Ying-Chen. 2021. Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis. In Environmental and molecular mutagenesis, 62, 409-421. doi:10.1002/em.22454. https://pubmed.ncbi.nlm.nih.gov/34331478/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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