Ankrd13d-KO Mouse

Ankrd13d, short for Ankyrin repeat domain-containing protein 13D, is involved in multiple biological processes. It contains ubiquitin-interacting motifs (UIM) and may act as a molecular scaffold in the endocytic pathway [2,3]. It has potential importance in diseases, as genes in the endocytic pathway, including Ankrd13d, may contribute to Alzheimer's disease [3].

In renal cell carcinoma, Ankrd13d was identified as a key immune regulator. It is mainly expressed in immune cells, positively correlated with Treg cell infiltration, and also with immune-related genes like PDCD1, CTLA4, etc. Targeting Ankrd13d with immune checkpoints blockade may be a promoting strategy for renal cell carcinoma immunotherapy [1].

In addition, in the context of heart failure, Ankrd13d was identified as a potential genetic contributor through an integrative transomics approach, although independent replication is needed [4]. Genome-wide association studies also found that Ankrd13d is associated with arachidonic acid in Hispanic Americans, indicating its role in fatty acid-related genetics [5,6]. In clear cell renal cell carcinoma, Ankrd13d has a strong positive correlation with TRIM46, suggesting its potential involvement in tumor-associated pathways [7].

In summary, Ankrd13d is implicated in immune regulation, endocytic processes, heart failure, fatty acid genetics, and renal cell carcinoma-related pathways. The findings from these studies contribute to understanding its role in various biological processes and disease conditions, potentially guiding future research and therapeutic strategies.