Dscc1-KO Mouse
Common Name
Dscc1-KO
제품 ID
S-KO-20080
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-72107-Dscc1-B6J-VB
상태
이 마우스 계통을 논문에서 사용할 경우, “Dscc1-KO Mouse (카탈로그 번호 S-KO-20080)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Dscc1-KO
품종 계통계통 ID
KOCMP-72107-Dscc1-B6J-VB
유전자명
제품 ID
S-KO-20080
유전자 별칭
Dcc1, 2010006I05Rik, 2600005O03Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 15
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000110231
NCBI 전사체 ID
NM_001355594
타겟 영역
Exon 2
유효 영역 크기
~1.5 kb
유전자 연구 개요
Dscc1, or DNA replication and sister chromatid cohesion 1, is involved in DNA replication, repair, and sister chromatid cohesion (SCC) as a component of the alternative replication factor C (RFC) complex [6]. It also plays a role in the DNA double-strand break (DSB) repair pathway choice, promoting homologous recombination (HR) repair during the S/G2 phase [5].
In mouse mutant lines, null mice for Dscc1 showed a significant increase in micronucleus (MN) formation, along with phenotypes characteristic of patients with cohesinopathy disorders [1]. In human cancers, high DSCC1 expression is associated with poor prognosis in lung adenocarcinoma (LUAD), gastric cancer, and breast cancer [2,4,10]. In LUAD, it promotes cell proliferation, stemness, EMT, and metastatic potential, and interacts with HSP90AB1 to regulate ER stress [3]. In gastric cancer, transcription factor E2F4 upregulates DSCC1 expression, promoting cell proliferation, migration, and invasion [7]. Also, multi-omics analyses suggest its potential as a pan-cancer biomarker and therapeutic target [8,9].
In conclusion, Dscc1 is crucial for maintaining genomic stability through its functions in DNA-related processes. Mouse models with Dscc1 knockout have revealed its role in conditions related to genomic instability, such as micronucleus formation and phenotypes similar to cohesinopathy disorders. In the context of cancer, high DSCC1 expression is often associated with poor prognosis and cancer progression, indicating its potential as a biomarker and therapeutic target in multiple cancer types.
References：
1. Adams, D J, Barlas, B, McIntyre, R E, Jackson, S P, Balmus, G. 2024. Genetic determinants of micronucleus formation in vivo. In Nature, 627, 130-136. doi:10.1038/s41586-023-07009-0. https://pubmed.ncbi.nlm.nih.gov/38355793/
2. Chang, Sisi, Zhu, Yahui, Xi, Yutan, Ma, Chunzheng, Li, Honglin. 2021. High DSCC1 Level Predicts Poor Prognosis of Lung Adenocarcinoma. In International journal of general medicine, 14, 6961-6974. doi:10.2147/IJGM.S329482. https://pubmed.ncbi.nlm.nih.gov/34707388/
3. Lin, Xu, Liu, Ye-Han, Zhang, Huan-Qi, Li, Yang-Ling, Hu, Jian. 2023. DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress. In Cancer cell international, 23, 208. doi:10.1186/s12935-023-03047-w. https://pubmed.ncbi.nlm.nih.gov/37742009/
4. Hou, Shiyang, Zhang, Jie, Chi, Xiaoqian, Kang, Chunbo, Shan, Haifeng. . Roles of DSCC1 and GINS1 in gastric cancer. In Medicine, 102, e35681. doi:10.1097/MD.0000000000035681. https://pubmed.ncbi.nlm.nih.gov/37904396/
5. Tian, Jiaxin, Li, Jiaheng, Liu, Fengqi, Zhang, Haoxing, Chen, Guo. 2025. DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair. In Cell reports, 44, 115452. doi:10.1016/j.celrep.2025.115452. https://pubmed.ncbi.nlm.nih.gov/40117291/
6. van Schie, Janne Jm, de Lint, Klaas, Pai, Govind M, Wolthuis, Rob Mf, de Lange, Job. 2022. MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC. In Life science alliance, 6, . doi:10.26508/lsa.202201596. https://pubmed.ncbi.nlm.nih.gov/36622344/
7. Baral, Shantanu, Yu, Yantao, Sun, Qiannan, Wang, Sen, Wang, Daorong. 2024. Transcription Factor E2F4 Promote Proliferation, Migration, and Invasion of Gastric Cancer Cells by transcriptionally activating DSCC1. In International journal of biological sciences, 20, 4978-4998. doi:10.7150/ijbs.99590. https://pubmed.ncbi.nlm.nih.gov/39309429/
8. Wang, Jingru, Gilani, Sana Fatima, Noor, Nazia, Hassan, Syed Sairum, Hameed, Yasir. 2024. Decoding the DSCC1 gene as a pan-cancer biomarker in human cancers via comprehensive multi-omics analyses. In American journal of translational research, 16, 738-754. doi:10.62347/YORR3755. https://pubmed.ncbi.nlm.nih.gov/38586115/
9. Cheng, Wei, Lin, Peng. 2025. DSCC1 Identified as Promising Tumor Biomarker and Potential Therapeutic Target Through Comprehensive Multi-omics Analysis and Experimental Validation. In Molecular biotechnology, , . doi:10.1007/s12033-025-01404-w. https://pubmed.ncbi.nlm.nih.gov/39992486/
10. Aljohani, Abrar I. 2024. Prognostic Significance of DSCC1, a Biomarker Associated with Aggressive Features of Breast Cancer. In Medicina (Kaunas, Lithuania), 60, . doi:10.3390/medicina60121929. https://pubmed.ncbi.nlm.nih.gov/39768811/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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